Posts by Gordon Fox
Problems with generic metoprolol
Many HCM patients have issues with metoprolol, the beta-blocker most widely prescribed for HCM. There may be multiple reasons for this, but a key one has been known for some time: many generic formulations of metoprolol succinate have time-release mechanisms that do not work in a similar fashion to the brand-name Toprol XL.
Read MoreThe Holidays Can Be Healthy For Your Heart
We’ve all had the experience: holidays can mean eating too much (much of which isn’t good for you), drinking too much, and getting no exercise. It doesn’t have to be like that! A new article in Cardiology Magazine (published by the American College of Cardiologists) suggests a strategy for heart-healthy holidays. There are strategies for…
Read MoreHCM and Mental Health
Learning that you have a serious chronic disease can be stressful. Now a group of researchers in Korea provide evidence (Park et al. 2022) that mental health problems can be an important consequence of diagnosis with HCM. Methods The research team was led by Hyung-Kwan Kim of Seoul National University. These scientists compared the risk…
Read MoreMavacamten Affects Diastolic Dysfunction
Background HCM patients commonly suffer from diastolic dysfunction (also called heart failure with preserved ejection fraction (HFpEF), or left-sided heart failure): their hearts do not fill adequately. As a result, even after septal reduction therapy (SRT: myectomy or alcohol septal ablation), some patients are quite symptomatic. Can mavacamten (Camzyos) help relieve their symptoms? Now a…
Read MoreExpert consensus on syncope in HCM
Syncope (fainting) is common among HCM patients, but its causes are frequently unknown. An expert panel has published guidelines for diagnosis and treatment of syncope in HCM.
Read MoreSeptal Myectomy Today
What’s the status of septal myectomy today? A recent review paper by an Expert Panel for the American Journal of Cardiology (Maron et al. 2022) concludes that “Surgical myectomy remains the time-honored primary treatment for hypertrophic cardiomyopathy patients with drug refractory limiting symptoms due to LV outflow obstruction.” One of the safest of heart procedures…
Read MoreCan HCM Patients Use Alcohol, Chocolate, & Coffee?
We hear many different claims about what HCM patients (or heart patients in general) should or shouldn’t eat and drink. This is a big topic, and for much of it, the science doesn’t have simple answers – at least not yet. But it turns out that there are some answers for three things that many people like (and many people won’t touch): wine, chocolate, and coffee.
Read MoreTraining and Experience Count: Myectomy is Safest at High-Volume Centers
Myectomy is safest at high-volume centers.
Read MoreUpdated thinking on HCM genetics
Since around 1990, HCM has been regarded as a disease caused entirely by single mutations in genes affecting a protein in the cardiac sarcomeres. There is no doubt that sarcomere mutations play an important role. But in the last several years, there has been a growing realization among researchers that this cannot be the entire explanation for the causes of HCM. This is because a majority of HCM patients do not appear to carry these mutations, and many people who do carry them never develop HCM. The development and inheritance of HCM are more complicated than was previously thought. However, for patients, many of the lessons previously taught about HCM genetics remain true. Current research may open the way to a much-improved understanding of HCM.
Read MoreMavacamten instead of septal reduction?
On April 2, Dr. Milind Y. Desai, a leading HCM researcher and practitioner, will present initial results on mavacamten’s use in severely obstructed HCM patients.
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