Welcome to Mayo Clinic in Rochester, Minnesota, the original and largest Mayo Clinic campus. Located in the heart of Rochester, Minnesota - a dynamic city just 90 minutes south of the Twin Cities of Minneapolis and St. Paul - Mayo Clinic has been safely caring for patients from around the world for more than 100 years.
Mayo Clinic will always be your safe care destination.
Michael Ackerman, MD - Director Pediatric and Genetics
Use points from credit cards or other loyalty programs to cover some or all of your travel costs.
Sign up for loyalty programs with credit cards, airlines, and hotels in order to earn points for your travel. This is particularly useful if you know you will be visiting your COE multiple times and can continue to accrue those points.
Considering joining AAA. Members receive excellent discounts, especially at hotels.
Travel Agency/Patient Travel Services
Mayo Clinic offers travel arrangements for patients and their families. Patient Travel Services (866-551-3392) can help you make flight reservations, changes to your travel itinerary, hotel reservations, and arrange ground transportation.
Concierge services
Mayo Clinic offers free concierge services (507-538-8438) including hotel, restaurant, and area business recommendations.
Lori Fund
The HCMA Lori Fund will provide micro travel grants to HCM patients traveling to an HCMA-recognized Center of Excellence for care or HCM patients traveling to a facility for heart transplant care. Awards up to $600.00 are available per calendar year.
Rochester International Airport (RST) is the closest airport to Mayo Clinic. It's a small airport with daily flights on American Airlines, Delta, and United. A staffed Mayo Clinic information booth and transportation desk are located near the baggage claim to help arrange transportation to your final destination.
Angel Flights East (215-358-1900) provides free air transportation to qualified patients and their families by arranging flights to distant medical facilities.
MiracleFlights (800-359-1711) provides free flights to those in need of life-changing medical care not available in their local communities.
Car
East-West highway routes: Interstate 90, US Hwy 14, State Hwy 30, State Hwy 42, State Hwy 296.
North-South highway routes: Interstate 35, US Hwy 52, US Hwy 63.
Amtrak offers daily passenger service between Chicago and Minneapolis/St. Paul. This service includes a scheduled stop in La Crosse, Wisconsin, where a connecting shuttle bus (one hour ride) provides transportation to Rochester. Amtrak provides daily train service between Chicago and the Pacific Northwest. The train departs from the Amtrak depot in Winona, located about 45 miles east of Rochester with shuttle service via Groome Transportation (507- 280-9270).
Bus
Jefferson Bus Lines (858-800-8898) offers service from Rochester to many cities, and it connects to Greyhound in Minneapolis.
Ground Services
Daily van shuttle service via Groome Transportation(507-280-9270) or Rochester Shuttle Service (888-998-9098) is available from MSP to Rochester, with shuttle drop-off at a number of Rochester hotels and other locations.
It is relatively easy to navigate Rochester, MN, as there are many available forms of transportation. Start here or here for an overview. Below are some specifics:
The Mayo Clinic provides downloadable pdfs and links to Google Maps for each of the main locations for their doctors’ offices and hospitals.
Parking is available at a number of ramps and surface lots near both the Downtown Campus and the Saint Mary’s Campus. A “ramp” is a parking garage. The ramps for the Downtown Campus are connected to each other and to the Mayo Clinic buildings via pedestrian subways so you don’t have to go outside.
Click here for additional information on parking in Rochester, MN.
The patient and visitor cafeteria is located on the street level of the Eisenberg Building. It serves breakfast, lunch, and dinner. The cafeteria is open from 7 a.m. to 7 p.m. every day including holidays. Visitors are welcome to have patients join them in the patient cafeteria.
The Skylight Commons in the subway level of the Mayo Building also serves breakfast and lunch, and is open from 7 a.m. to 2 p.m. every day.
St Mary's campus
The patient and visitor cafeteria is on the main floor of the Francis Building. It features a complete breakfast menu, hot entrees, pizza, grilled and deli sandwiches, soups, salad bar and desserts. All food is available for takeout.
The Saint Marys Campus visitor cafeteria is open seven days a week from 7 a.m. to 7 p.m.
The Mayo Clinic is among the most wheelchair-friendly destinations you can find, and they offer accessibility services for all special needs and disabilities. Their services include patient escorts, wheelchairs, strollers, handicap-accessible parking, hearing-impaired services, and accessible restrooms.
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The city of Rochester, MN revolves around the Mayo Clinic, resulting in an abundance of options for lodging, food, and activities for patients and their travel companions. While the spring, summer, and fall at the Mayo Clinic provide for some milder temperatures, visitors at all times of year, but particularly during the harsh Minnesota winter, should come prepared to bundle up. There is a system of tunnels on the Downtown Campus of the Mayo Clinic, called the Skyway/Subway, that connects several of the Clinic’s main buildings to a food court, shops, and a number of hotels. If you stay in one of those hotels, you can get to your COE appointment without venturing outside. To learn the basics for Mayo Clinic patients and visitors, click here. For a deep dive into all of your travel options, expand each of the categories provided on this page. To dig into local lodging, including hotels and short-term rentals, scroll down, and click on the tab of your choice.
Lodging
There is no shortage of available hotels and short-term rentals in the Rochester, MN area, so your choice of where to stay depends largely on your preferences. Start here for an overview. Click on the tabs above for our specific recommendations.
A few items of note:
The Center of Excellence itself is located in the Mayobuilding at 200 1st Avenue SW on the Main Campus in Downtown Rochester. Many surgeries and procedures are done at the hospital on the Saint Mary’s Campus. You may want to select lodging that is closer to one or the other. There is a free shuttle that travels back and forth between the two.
Anderson Wheelchair Rentals (507-512-7899) is a great source for medical equipment and supply rentals, such as reclining chairs, adjustable beds, and bathroom safety items, and they deliver locally.
Hotels
The annual average nightly hotel room rate in Rochester, MN (excluding taxes) is $133 in 2023.
To begin your hotel search, click here, and set the filters on the left to search for all of the typical amenities you seek. Outside of the usual filters such as free parking, free continental breakfast, and high-speed wireless internet, there are Mayo Clinic-specific filters available.
We’ve also researched some HCM patient-friendly amenities you may wish to take advantage of, including patient pricing discounts, connecting rooms, kitchenette, and the availability of recliners. Many lodging options that do not include a kitchenette do have refrigerators and/or microwaves available to guests. You may need to request them in advance.
We hope you’ll use the list below to assist in your hotel search:
3-star hotel; 10% discount for Mayo Clinic patients; call in advance to request the medical reclining chair; connecting rooms are available but not guaranteed.
3-star hotel; A "Wellness Hotel." Patient discount fluctuates based on availability. Located next door toAnderson Wheelchair Rentals.Connecting rooms available but not guaranteed. EVEN is located in the same building as Staybridge Suites.
2.5-star hotel; Patient discount fluctuates, depending on the date. They are almost always able to fulfill connecting room requests and won't make the reservation if they can't. Be sure to ask for your recliner when you make your reservation. The height of the bed can be lowered upon request.
3-star hotel; Patient discount is approximately 25% but varies by date and availability. Many rooms have recliners in them already, but be sure to request one upon reservation if you need it.
3-star hotel; Mayo Clinic patient rate varies based on how full the hotel is. Connecting rooms can be guaranteed at time of reservation. Suites have recliners in them, and a recliner can be moved to any room for a $25 fee.
3-star hotel; Mayo Clinic patient rate varies based on date and how full the hotel is. Guaranteed connecting rooms can only be booked online. Make your request for a recliner at the time of reservation.
3-star hotel; Mayo clinic patient rate is 15-20% off, varying by day of the week. They can't guarantee connecting rooms but do their best to accommodate.
3-star hotel; Patient discount fluctuates based on availability. Anderson Wheelchair Rentals is located next door. Connecting rooms are available but not guaranteed. Staybridge Suites are located in the same building as EVEN Hotel.
COE Discount Available
Connecting Rooms Available
Kitchenette
Handicap Accessible
Courtesy Clinic Shuttle
Google Top 5
Short-Term (AirBnB/VRBO)
Short-term rentals are available in the Rochester area and this chart includes sole occupancy/single unit properties near the Mayo Clinic with one or more accessibility features such as no stairs, extra wide doors, or grab bars in the bathroom.
Travel information is provided through a collaboration between The Hypertrophic Cardiomyopathy Association and Reasonable Accommodations LLC.
The HCMA and Reasonable Accommodations will make their best effort to keep the Patient Travel Planning Guide as current as possible. The HCMA cannot give any guarantees with regard to the prices, opening times, and availability of any specified facilities. Additionally, just because facilities are mentioned does not necessarily mean that these will always be available. Changes may also have been made to the specified prices, opening times, and availability.